Image for Cardiovascular Pharmacology Concepts, Richard E Klabunde PhD

Cardiovascular Pharmacology Concepts

Richard E. Klabunde, PhD

Clinical Disorders:

Therapeutic Classes:

Mechanism Classes:


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Click here for information on Cardiovascular Physiology Concepts, 2nd edition, a textbook published by Lippincott Williams & Wilkins (2011)

 

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Click here for information on Normal and Abnormal Blood Pressure, a textbook published by Richard E. Klabunde (2013)





Antianginal Drugs

Therapeutic Use and Rationale

Rationale for Treating Angina

Increase Oxygen Delivery:
  • Coronary vasodilators
  • Anti-thrombotic drugs

Decrease Oxygen Demand:
  • Vasodilators
    (reduce afterload and preload)
  • Cardiac depressants
    (reduce heart rate and contractility)

Angina results from a reduction in the oxygen supply/demand ratio. Therefore, in order to alleviate the pain, it is necessary to improve this ratio. This can be done either by increasing blood flow (which increases oxygen delivery or supply), or by decreasing oxygen demand (i.e., by decreasing myocardial oxygen consumption).

Pharmacologic interventions that block coronary vasospasm (coronary vasodilators) or inhibit clot formation are used to treat variant and unstable angina, respectively. These drugs act by increasing coronary blood flow and oxygen supply, or by preventing vasospasm and clot formation, and associated decreases in blood flow. Drugs that reduce myocardial oxygen demand are also given to patients with these two forms of angina to reduce oxygen demand and thereby help to alleviate the pain.

Drugs that reduce myocardial oxygen demand are commonly used to prevent and treat episodes of ischemic pain associated with fixed stenotic lesions (i.e., chronic stable angina).  Some of these drugs reduce oxygen demand by decreasing heart rate (decreased chronotropy) and contractility (decreased inotropy), while other drugs reduce afterload and or preload on the heart. Afterload and preload reducing drugs act by dilating peripheral arteries and veins. Direct vasodilation of the coronary arteries is ineffective as a therapeutic approach and may actually worsen the ischemia by producing coronary vascular steal.

Classes of Drugs Used to Treat Angina

Classes of drugs used in the treatment of angina and myocardial infarction are given below.  Clicking on the drug class will link you to the page describing the pharmacology of that drug class.

Revised 03/15/07

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.