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Cardiovascular Pharmacology Concepts

Richard E. Klabunde, PhD

Clinical Disorders:

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The Pharmacologic Treatment of Cardiac Arrhythmias cont

Causes of Arrhythmias

Bradycardia

Sinus bradycardia results from reduced SA nodal firing rate. This can occur because of excessive vagal stimulation (e.g., during fainting) or because of damage to the SA node (e.g., damage caused by ischemia or disease). Ventricular bradycardia usually occurs as a result of AV block, which leads to the expression of a pacemaker site within the ventricles that fires at a slow rate (30-40 beats/min).

Tachycardia

Sinus tachycardia most commonly results from excessive sympathetic nerve stimulation of the SA node or high circulating levels of catecholamines (e.g., pheochromocytoma). Sinus tachycardia that occurs during exercise, for example, is physiologic and normal. However, sinus tachycardia at rest is not normal. Atrial (non-sinus) tachycardia can occur due to either an ectopic foci firing at a high frequency or to reentry mechanisms within the atria. Both of these mechanisms may be stimulated by ischemia or increased sympathetic activity. Supraventricular tachycardia caused by global reentry involves an abnormal conduction pathway. For example, accessory pathways between the right atrium and right ventricle (Bundle of Kent) can cause Wolff-Parkinson-White syndrome. Reentry within the AV node can also precipitate a supraventricular tachycardia. These reentry mediated tachycardias can be triggered by elevated sympathetic activity, which alters conduction velocity within the cardiac tissue and the effective refractory period of action potentials. In some forms of heart disease, ventricular and or atrial dilation occurs, which can lead to tachyarrhythmias or premature beats. Fibrillation is usually caused by diseased ischemic myocardium.

Premature Beats

Atrial and ventricular premature beats are seen as premature atrial complexes (PAC) or premature ventricular complexes (PVC) on the electrocardiogram. These premature beats can be caused by disturbances that increase the excitability of cardiac cells. Stretching of the tissue and ischemia are common causes. Increased sympathetic activity and circulating catecholamines can also precipitate premature beats.

Conduction Blocks

AV conduction blocks can occur during excessive vagal stimulation or removal of normal sympathetic influences on the AV node, which tips the autonomic balance toward a more dominant vagal influence. This can occur, for example, as a consequence of beta1-adrenoceptor blockade. The most common cause of AV conduction blocks is changes in the electrophysiological properties of the specialized cells within the AV node and Bundle of His. Ischemia, damage caused by trauma, infection or inflammation, or degenerative changes caused by age or disease can lead to AV conduction blocks. These same mechanisms (except for vagal) can cause conduction blocks in other regions of the conduction system, such as the bundle branches.

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Antiarrhythmic Drugs

Revised 03/14/07

DISCLAIMER: These materials are for educational purposes only, and are not a source of medical decision-making advice.